Protein Details: Chloride channel protein ClC-Kb

Protein ID

ICDB_Pro_1698

Protein Name

Chloride channel protein ClC-Kb

Gene Name

Clcnkb; Clckb; Clcnk1l

Organism

Mus musculus (Mouse)

Length

687 amino acids

AlphaFoldDB

AF-Q9WUB6-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells.

Sequence

MEELVGLREGASKKPVPLQELWGPCPRIRRNIQGGLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFTIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPESKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNNEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYSQRTFLFFLKANGFTSKLLATSKPLYSALAAVVLASITYPPGVGHFMASRLSMSEHLETLFDNNSWALMTKNSSPPWAAEPDPQKLWLEWCHPQLTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFIYGAVIGRLFGEVLSVAFPEGIVAGGRVNPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVTGQLVHALPVLMAVLAANAISQSFQPSFYDGTIIVKKLPYLPWIRGRQIGSHSVTVGHFMNCALTTLAKDMPLEQVIQVVISTDVTQYPLVETTESQTLVGVVKRTHLVQALQTEPASWAPGQQPCLQDILANGCPTQPVTLQLSLETSLHETHNLFELLNLQTLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 121; /ligand="chloride" ; BINDING 259; /ligand="Ca(2+)"; BINDING 261; /ligand="Ca(2+)"; BINDING 278; /ligand="Ca(2+)"; BINDING 281; /ligand="Ca(2+)"; BINDING 426; /ligand="chloride"

Disease

Location

Specifically expressed in the kidney. All nephron segments expressing BSND also express CLCNK proreins.

DOI ID

10.1007/s002320010005; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1038/35107099; 10.1016/j.cell.2010.12.001

RefSeq

NP_062675.2 [Q9WUB6-1]; XP_011248609.1 [Q9WUB6-1]